Essays in biochemistry mitochondrial function


The early years: mitochondria as the centers of cellular respiration

Free Radical Biology and Medicine , 85 , Impaired mitochondrial energy metabolism in Alzheimer's disease: Impact on pathogenesis via disturbed epigenetic regulation of chromatin landscape. Progress in Neurobiology , , Metabolic control of signalling pathways and metabolic auto-regulation. Biology of the Cell , 8 , Hoffmann, Carsten Jaeger, Katja E.

SIRT3 deficiency impairs mitochondrial and contractile function in the heart. The role of mammalian sirtuins in cancer metabolism. Mitochondrial complex II is a source of the reserve respiratory capacity that is regulated by metabolic sensors and promotes cell survival. Sirtuins and the Metabolic Hurdles in Cancer. Current Biology , 25 13 , RR Chinese Medical Journal , 12 , Kyle G. Cheung, Laura K. Hatch, Qiang Tong, Vernon W. Journal of Biological Chemistry , 17 , Surinder Kumar, David B.

Mechanisms of cell death pathway activation following drug-induced inhibition of mitochondrial complex I. Redox Biology , 4 , Frontiers in Immunology , 6 DOI: Kate J. Claycombe, James N. Vomhof-DeKrey, W. Thomas Johnson. Skeletal muscle Sirt3 expression and mitochondrial respiration are regulated by a prenatal low-protein diet.


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The Journal of Nutritional Biochemistry , 26 2 , Mitochondrial sirtuins: Emerging roles in metabolic regulations, energy homeostasis and diseases. Experimental Gerontology , 61 , Yeng F. Her, L. James Maher. International Journal of Endocrinology , , Resveratrol regulates mitochondrial reactive oxygen species homeostasis through Sirt3 signaling pathway in human vascular endothelial cells. Mills, James H. Over-expression of the Sirt3 sirtuin Protects neuronally differentiated PC12 Cells from degeneration induced by oxidative stress and trophic withdrawal.

Brain Research , , Sirt3 attenuates hydrogen peroxide-induced oxidative stress through the preservation of mitochondrial function in HT22 cells. International Journal of Molecular Medicine , 34 4 , Impact of acetylation on tumor metabolism. Wagg, Natasha Fillmore, Jagdip S.

Jaswal, Michael N. Sack, Richard Lehner, Mahesh P. Gupta, Evangelos D. Michelakis, Raj S. Padwal, David E. Johnstone, Arya M. Sharma, Gary D. Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling. SIRT3 is a novel prognostic biomarker for esophageal squamous cell carcinoma. Medical Oncology , 31 8 DOI: Journal of Integrative Agriculture , 13 8 , Annette Hofer, Tina Wenz.

Post-translational modification of mitochondria as a novel mode of regulation. Experimental Gerontology , 56 , Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation. Biochemical Society Transactions , 42 4 , Motiur Rahman, Niraj K. Shaw, David G. Lambright, Jairaj K. Acharya, Usha R. The Journal of Cell Biology , 2 , Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process. Ageing Research Reviews , 16 , Pacella-Ince, D. L Zander-Fox, M.

Mitochondrial SIRT3 and its target glutamate dehydrogenase are altered in follicular cells of women with reduced ovarian reserve or advanced maternal age. Human Reproduction , 29 7 , George A. Porter, William R. Urciuoli, Paul S. Brookes, Sergiy M. SIRT3 deficiency exacerbates ischemia-reperfusion injury: implication for aged hearts. Cell Metabolism , 19 6 , Jee-Eun Choi, Raul Mostoslavsky. Sirtuins, metabolism, and DNA repair.

British Journal of Pharmacology , 12 , An integrated perspective and functional impact of the mitochondrial acetylome. Expert Review of Proteomics , 11 3 , Evanna Mills, Luke A. Succinate: a metabolic signal in inflammation. Trends in Cell Biology , 24 5 , Fatiha Nassir, Jamal Ibdah.

International Journal of Molecular Sciences , 15 5 , Pamela J. Kaisaki, Georg W. Otto, Joanna F. Kessler, Dominique Gauguier, Richard Mott,. Rebeca Acin-Perez, Jose A. The function of the respiratory supercomplexes: The plasticity model. Brenna Osborne, Gregory J. Cooney, Nigel Turner. Are sirtuin deacylase enzymes important modulators of mitochondrial energy metabolism?. Sadhana A. Samant, Hannah J. Zhang, Zhigang Hong, Vinodkumar B. Pillai, Nagalingam R. Sundaresan, Donald Wolfgeher, Stephen L.

Mitochondria Essay

Archer, David C. Chan, Mahesh P. Molecular and Cellular Biology , 34 5 , Akie, David C. Hoaglin, Guangping Gao, John F. Keaney, Marcus P. Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. Journal of Clinical Investigation , 2 , Vinodkumar B. Sundaresan, Mahesh P.

Regulation of Akt Signaling by Sirtuins. Circulation Research , 2 , Stephan Winnik, Daniel S. Miranda, Yilei Liu, Lambertus J. Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development. Evidence-Based Complementary and Alternative Medicine , , Journal of Biological Chemistry , 51 , Tiffany Tuyen M. Sack, Elizabeth Murphy. Cyclophilin D Modulates Mitochondrial Acetylome. Circulation Research , 12 , Mitochondrial dysfunction in rabies virus infection of neurons.

Journal of NeuroVirology , 19 6 , Calorie restriction influences key metabolic enzyme activities and markers of oxidative damage in distinct mouse liver mitochondrial sub-populations. Life Sciences , 93 24 , Julia Brenmoehl, Andreas Hoeflich. Dual control of mitochondrial biogenesis by sirtuin 1 and sirtuin 3. Mitochondrion , 13 6 , Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: A possible role for SirT3 activation. Gius, Athanassios Vassilopoulos. Metabolic regulation of Sirtuins upon fasting and the implication for cancer.

Current Opinion in Oncology , 25 6 , Gilles Gouspillou, Russell T. Facts and controversies in our understanding of how caloric restriction impacts the mitochondrion. Experimental Gerontology , 48 10 , Flint Beal, Emmanuel Brouillet. A role of mitochondrial complex II defects in genetic models of Huntington's disease expressing N-terminal fragments of mutant huntingtin.

Human Molecular Genetics , 22 19 , Amelia J. Still, Brendan J. Floyd, Alexander S. Hebert, Craig A. Bingman, Joshua J. Carson, Drew R. Gunderson, Brendan K. Dolan, Paul A. Grimsrud, Kristin E. Dittenhafer-Reed, Donald S. Stapleton, Mark P. Keller, Michael S.

Mitochondria structure and function - Cell Physiology medical animation

Westphall, John M. Denu, Alan D. Attie, Joshua J. Coon, David J. Journal of Biological Chemistry , 36 , Moritz Osterholt, T. Alterations in mitochondrial function in cardiac hypertrophy and heart failure. Heart Failure Reviews , 18 5 , Free Radical Biology and Medicine , 61 , Rack, Mathias Ziegler. FEBS Journal , 15 , Devine, Robert N. The Cardiac Acetyl-Lysine Proteome. Alexandra S. Bause, Marcia C. SIRT3 regulation of mitochondrial oxidative stress.

Experimental Gerontology , 48 7 , Interaction of Sirt3 with OGG1 contributes to repair of mitochondrial DNA and protects from apoptotic cell death under oxidative stress. Sean A. Newsom, Kristen E. Boyle, Jacob E. Sirtuin 3: a major control point for obesity-related metabolic diseases?.


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Drug Discovery Today: Disease Mechanisms , 10 , ee Mitochondrial complex II, a novel target for anti-cancer agents. Bora E. Mitochondrial complex II and genomic imprinting in inheritance of paraganglioma tumors. Andrew P. Wojtovich, C. Owen Smith, Cole M. Haynes, Keith W. Nehrke, Paul S. Differential effects of complex II on mitochondrial ROS production and their relation to cardioprotective pre- and postconditioning. Rardin, J. Newman, J. Held, M. Cusack, D. Sorensen, B. Li, B. Schilling, S. Mooney, C. Kahn, E. Verdin, B. Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.

Proceedings of the National Academy of Sciences , 16 , Jessica A. Hall, John E. Dominy, Yoonjin Lee, Pere Puigserver. Journal of Clinical Investigation , 3 , Andersen, Sally Kornbluth. The Tangled Circuitry of Metabolism and Apoptosis. Molecular Cell , 49 3 , Mechanisms of Bioenergy Production in Mitochondria. Pillai, Mahesh P. Etienne Hebert-Chatelain.

Src kinases are important regulators of mitochondrial functions. Ghinis-Hozumi, A. Antaramian, F. Villarroya, E. Potential role of sirtuins in livestock production. Vadvalkar, C. Biochemical Journal , 1 , John C. Newman, Wenjuan He, Eric Verdin. Eri Maria Sol, Sebastian A. Wagner, Brian T. Mitochondrial sirtuins and metabolic homeostasis. Richard C. Nucleus-encoded regulators of mitochondrial function: Integration of respiratory chain expression, nutrient sensing and metabolic stress. Emine C. Koc, Hasan Koc.

Regulation of mammalian mitochondrial translation by post-translational modifications. Lydia W. Finley, Marcia C. Metabolic regulation by SIRT3: implications for tumorigenesis. Trends in Molecular Medicine , 18 9 , Wenjuan He, John C. Newman, Margaret Z. Wang, Linh Ho, Eric Verdin. Mitochondrial sirtuins: regulators of protein acylation and metabolism.

An anticancer agent, pyrvinium pamoate inhibits the NADH—fumarate reductase system—a unique mitochondrial energy metabolism in tumour microenvironments. The Journal of Biochemistry , 2 , Amanda T. White, Simon Schenk. Yue Xiong, Kun-Liang Guan. Mechanistic insights into the regulation of metabolic enzymes by acetylation. Cichewicz, Serena A. Hageman, Trevor K.


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  4. Ross, Wenzhen Duan. Journal of Biological Chemistry , 29 , Ruben Nogueiras, Kirk M. Banks, Marcelo O. Dietrich, Tamas L. Horvath, David A. Sinclair, Paul T. Pfluger, Matthias H. Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism. Physiological Reviews , 92 3 , Michael Gaster, Jan O. Nehlin, Ariane D. Impaired TCA cycle flux in mitochondria in skeletal muscle from type 2 diabetic subjects: Marker or maker of the diabetic phenotype?. Archives of Physiology and Biochemistry , 3 , Gregory R. Wagner, P. Melanie Pride, Clifford M. Babbey, R. Friedreich's ataxia reveals a mechanism for coordinate regulation of oxidative metabolism via feedback inhibition of the SIRT3 deacetylase.

    Introduction

    Human Molecular Genetics , 21 12 , Mitochondrial Regulation by Protein Acetylation. Rice, M. Sun, K. Kemp, E. Gray, A. Wilkins, N. Mitochondrial sirtuins - a new therapeutic target for repair and protection in multiple sclerosis. European Journal of Neuroscience , 35 12 , The updated biology of hypoxia-inducible factor. Kristin A.

    Anderson, Matthew D. Mitochondrial protein acetylation regulates metabolism. Essays In Biochemistry , 52 , Albert Giralt, Francesc Villarroya. SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.

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    Angeliki Chalkiadaki, Leonard Guarente. Sirtuins mediate mammalian metabolic responses to nutrient availability. Nature Reviews Endocrinology , 8 5 , Birgit Schilling, Matthew J. Rardin, Brendan X. MacLean, Anna M. Zawadzka, Barbara E. Frewen, Michael P. Cusack, Dylan J. Sorensen, Michael S. Bereman, Enxuan Jing, Christine C. Wu, Eric Verdin, C. Ronald Kahn, Michael J. MacCoss, Bradford W. X Charlie Dong. Sirtuin biology and relevance to diabetes treatment.

    Diabetes Management , 2 3 , Larner, Edward J. Cytoprotection by the modulation of mitochondrial electron transport chain: The emerging role of mitochondrial STAT3. Mitochondrion , 12 2 , Michael N. The role of SIRT3 in mitochondrial homeostasis and cardiac adaptation to hypertrophy and aging. Journal of Molecular and Cellular Cardiology , 52 3 , Epigenetics of Diabetes in Humans.

    Bradley R. Webster, Zhongping Lu, Michael N. Sack, Iain Scott. The role of sirtuins in modulating redox stressors. Free Radical Biology and Medicine , 52 2 , Claudia V. Pereira, Magda Lebiedzinska, Mariusz R. Wieckowski, Paulo J. Regulation and protection of mitochondrial physiology by sirtuins. Mitochondrion , 12 1 , Jean-Pierre Bayley, Peter Devilee. The Warburg effect in Current Opinion in Oncology , 24 1 , Caton, J. Kieswich, M. Yaqoob, M. Holness, M. Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function.

    Diabetologia , 54 12 , Emerging characterization of the role of SIRT3-mediated mitochondrial protein deacetylation in the heart. Sirtuin 1 SIRT1. Journal of Biomolecular Screening , 16 10 , Basic Research in Cardiology , 6 , Stephen J. Pharmaceutical Research , 28 11 , Vosler, Yanqin Gao, Michael J. Zigmond, Jun Chen.

    Protective effects and mechanisms of sirtuins in the nervous system. Progress in Neurobiology , 95 3 , Greg M. Landry, Sarah Martin, Kenneth E. Cellular and molecular effects of sirtuins in health and disease. Clinical Science , 5 , Cha, J. International Journal of Molecular Sciences , 12 9 , Wallace, Vincent Procaccio, Steven P.

    Gygi, Marcia C. Turki Y. SIRT3 and cancer: Tumor promoter or suppressor?. Caloric excess or restriction mediated modulation of metabolic enzyme acetylation—proposed effects on cardiac growth and function. Lei Zhong, Raul Mostoslavsky. Cell Metabolism , 13 6 , Bell, Leonard Guarente. Molecular Cell , 42 5 , DePinho, X. Charlie Dong. Journal of Biological Chemistry , 16 , Cancer Cell , 19 3 , Kun-Liang Guan, Yue Xiong. Regulation of intermediary metabolism by protein acetylation.

    Trends in Biochemical Sciences , 36 2 , Sack, Enxuan Jing, C. Fatty liver is associated with reduced SIRT3 activity and mitochondrial protein hyperacetylation. Biochemical Journal , 3 , David B. Lombard, Daniel X. Tishkoff, Jianjun Bao. Thomas Koeck, Anders H.

    When mitochondria stop functioning, the cell they are in is starved of energy. So, depending on the type of cell, symptoms can vary widely.

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    As a general rule, cells that need the largest amounts of energy, such as heart muscle cells and nerves, are affected the most by faulty mitochondria. Diseases that generate different symptoms but are due to the same mutation are referred to as genocopies. Conversely, diseases that have the same symptoms but are caused by mutations in different genes are called phenocopies.

    An example of a phenocopy is Leigh syndrome , which can be caused by several different mutations. Over recent years , researchers have investigated a link between mitochondria dysfunction and aging. There are a number of theories surrounding aging, and the mitochondrial free radical theory of aging has become popular over the last decade or so.

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    The theory is that reactive oxygen species ROS are produced in mitochondria, as a byproduct of energy production. These highly charged particles damage DNA, fats, and proteins. Because of the damage caused by ROS, the functional parts of mitochondria are damaged. When the mitochondria can no longer function so well, more ROS are produced, worsening the damage further. Although correlations between mitochondrial activity and aging have been found, not all scientists have reached the same conclusions. Their exact role in the aging process is still unknown. Mitochondria are, quite possibly, the best-known organelle.

    And, although they are popularly referred to as the powerhouse of the cell, they carry out a wide range of actions that are much less known about. From calcium storage to heat generation, mitochondria are hugely important to our cells' everyday functions. Article last reviewed by Thu 8 February All references are available in the References tab. Adams, J. Human Evolutionary Tree. Nature Education, 1 1 , Bratic, A. The role of mitochondria in aging.

    The Journal of Clinical Investigation, 3 , — Chan, D. Mitochondria: Dynamic organelles in disease, aging, and development. Cell, 7 , — Chial, H. DiMauro, S. Mitochondrial DNA and disease. Annals of Medicine, 37 3 , — Klinge, C. Estrogenic control of mitochondrial function and biogenesis. Journal of Cellular Biochemistry, 6 , — Leigh syndrome.

    Mishra, P. Mitochondrial dynamics and inheritance during cell division, development and disease. Nature Reviews Molecular Cell Biology, 15 10 , — Mitochondrion — much more than an energy converter. Mozo, J. Thermoregulation: What role for UCPs in mammals and birds?. Bioscience Reports, 25 3—4 , — Oliveira, G. Oliveira, C. Mitochondrial dysfunction in autism spectrum disorders: A population-based study.

    Developmental Medicine and Child Neurology, 47 3 , — Rossier, M. T channels and steroid biosynthesis: In search of a link with mitochondria. Cell Calcium, 40 2 , — Taylor, S. Ghosh, S. Characterization of the human heart mitochondrial proteome. Nature Biotechnology, 21 3 , — Wang, C.

    The role of mitochondria in apoptosis. Annual Review of Genetics, 43 , 95— What is mitochondrial disease? MLA Newman, Tim. MediLexicon, Intl. APA Newman, T. MNT is the registered trade mark of Healthline Media. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Privacy Terms Ad policy Careers. Visit www. All rights reserved. More Sign up for our newsletter Discover in-depth, condition specific articles written by our in-house team.

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    Send securely. Message sent successfully The details of this article have been emailed on your behalf. By Tim Newman. Reviewed by Daniel Murrell, MD. A basic diagram of a mitochondrion. Mitochondria are important in a number of processes. If mitochondria do not function correctly, it can cause a range of medical problems. Parkinson's disease: Could the answer lie in mitochondria of dopamine cells? Dopamine cells in Parkinson's brains are less protected from age-related damage in their mitochondrial DNA than cells in healthy brains.

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    essays in biochemistry mitochondrial function Essays in biochemistry mitochondrial function
    essays in biochemistry mitochondrial function Essays in biochemistry mitochondrial function
    essays in biochemistry mitochondrial function Essays in biochemistry mitochondrial function
    essays in biochemistry mitochondrial function Essays in biochemistry mitochondrial function
    essays in biochemistry mitochondrial function Essays in biochemistry mitochondrial function

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